ACEI or ARB not associated with more severe COVID-19 disease. Despite initial concerns, high-certainty evidence shows that this drug classes are not related with covid severity. Besides, moderate-certainty evidence suggests they're not linked to positive SARS-CoV-2 test results in symptomatic patients. Whato we don't know is whether they increase the risk for mild or asymptomatic disease or are beneficial in COVID-19 treatment.
Levothyroxine therapy is ineffective for symptom relief in adults >65 with subclinical hypothyroidism. Secondary analysis of TRUST trial where 638 adults >65 with TSH 4,6-20 mcU/mL. More than 100 had high scores of symptoms suggestive of thyroid dysfunction. But in this subgroup the authors saw no improvement in the Levothyroxine arm compared to placebo.
A case of Graves Disease with TSH receptor blocking antibodies during pregnancy. Sometimes we forget that in Graves Disease hypothyroidism could develop due to blocking TSH-r blocking Ab because stimulating Ab usally predominate. In this patient, these Ab were identified and their pregnancies treated with levothyroxine to prevent fetal hypothyroidism. In both pregnancies thyroid fetal function was normal, but presistence of maternal blocking Ab caused transient hypothyroidis in postpartum.
